For a short time following his awakening, she co-piloted Gurren Lagann with Simon until she saw that there was nothing she could do to aid him in that realm; he could actually pilot the Gurren Lagann by himself. Yoko is shown to be very mature and quite knowledgeable, especially when it comes to survival and general common sense. She is a fourteen  year old girl from Jeeha's neighboring village of Littner who had been chasing the Gunmen that crashed into Jeeha Village during the events of Episode 1. However, she reaches forward to touch the screen before it shuts off, thanking Kamina and heading off to help Simon. This incident caused Yoko to hold a grudge against Nia Teppelin and develop a deep resentment towards her. Unfortunately, Kamina was unable to fulfill that promise as he was killed. At first, she wears an outfit similar to the one she wore in part 1, only with the notable addition of a dark maroon jacket similar in style to what Simon wore in part 1, thigh-high variants of her old boots and no stockings.
She watches Simon's speech and is in awe while commenting that he needs some work.
She couldn't understand Kamina's blind faith in him as she believes him not to be the fighting type due to his inability to cope under pressure. Even though Yoko acknowledged that no amount of crying would bring Kamina back, she still believed that they couldn't just forget about him like he was nothing. She frees Simon and Viral at Simon's request and helps them by piloting the Dayakkaiser into battle.